TABLE 2.
Associations between douching, talc use, and uterine cancer in the Sister Study
| Full cohort, N(%) | Uterine cancer cases, N(%) | Adjusted Hazard Ratiob | |
|---|---|---|---|
| N=33,609a | N=271a | ||
| Douching | |||
| Ever | |||
| No | 28,459 (85) | 231 (86) | 1.0 |
| Yes | 4,896 (15) | 37 (14) | 1.0 (0.72, 1.5) |
| Frequencyc | |||
| None | 28,459 (85) | 231 (86) | 1.0 |
| Sometimes | 3,969 (12) | 31 (12) | 1.1 (0.73, 1.5) |
| Frequently | 927 (2.8) | 6 (2.2) | 0.86 (0.37, 2.0) |
| p-trend= 0.96 | |||
| Ever in past 12 months | |||
| No | 29,139 (87) | 234 (88) | 1.0 |
| Yes | 4,201 (13) | 33 (12) | 1.1 (0.75, 1.6) |
| Ever, ages 10–13 | |||
| No | 32,183 (97) | 259 (98) | 1.0 |
| Yes | 961 (2.9) | 5 (1.9) | 0.67 (0.28, 1.6)d |
| Talc use | |||
| Ever | |||
| No | 24,250 (74) | 178 (66) | 1.0 |
| Yes | 8,686 (26) | 90 (34) | 1.2 (0.94, 1.6) |
| Frequencyc | |||
| None | 24,250 (74) | 178 (66) | 1.0 |
| Sometimes | 5,610 (17) | 51 (19) | 1.1 (0.81, 1.5) |
| Frequently | 3,076 (9.3) | 39 (15) | 1.4 (0.99, 2.0) |
| p-trend= 0.07 | |||
| Ever in past 12 months | |||
| No | 28,299 (86) | 221 (82) | 1.0 |
| Yes | 4,625 (14) | 47 (18) | 1.1 (0.82, 1.6) |
| Ever, ages 10–13 | |||
| No | 25,940 (82) | 198 (77) | 1.0 |
| Yes | 5,847 (18) | 59 (23) | 1.2 (0.90, 1.6)d |
| Long-term use (age 10–13 and last 12 months) | |||
| No | 29,989 (94) | 244 (94) | 1.0 |
| Yes | 1,786 (5.6) | 16 (6.2) | 1.1 (0.65, 1.8)d |
| Combined use | |||
| Ever | |||
| Neither | 21,344 (65) | 159 (60) | 1.0 |
| Both | 1,840 (5.6) | 18 (6.8) | 1.3 (0.79, 2.1) |
| Talc/no douching | 6,715 (21) | 20 (26) | 1.2 (0.90, 1.6) |
| Douching/no talc | 2,783 (8.5) | 18 (6.8) | 0.98 (0.60, 1.6) |
| Ever in past 12 months | |||
| Neither | 25,023 (77) | 195 (74) | 1.0 |
| Both | 968 (3.0) | 9 (3.4) | 1.2 (0.64, 2.4) |
| Talc/no douching | 3,586 (11) | 37 (14) | 1.1 (0.79, 1.6) |
| Douching/no talc | 3,082 (9.4) | 23 (8.7) | 1.1 (0.68, 1.7) |
Missing: Ever douching and douching frequency (254 from cohort, including 3 cases), douching last 12 months (269 from cohort, including 4 cases), douching age 10–13 (465 from cohort, including 4 cases), ever talc use and talc use frequency (673 from cohort, including 3 cases), talc last 12 months (685 from cohort, including 3 cases), talc use ages 10–13 (1,822 in cohort, including 11 cases), long-term talc use (1,834 in cohort, including 11 cases), both ever (927 in cohort, including 6 cases), both in last 12 months (950 in cohort, including 7 cases)
Participants with complete confounder information.
Adjusted for race/ethnicity, education, body mass index (restricted cubic spline), menopausal status, parity, duration of oral contraceptive use, hormone therapy use, smoking, alcohol use, and age at menarche.
Sometimes users used <1/month in the last year or “sometimes” ages 10–13, regular users used ≥1/month in the last year or “frequently” ages 10–13
Adjusted for race/ethnicity, age at menarche and relative weight at age 10 only, had to be non-missing for other covariates