Table 2.
Allograft outcomes after kidney transplantation
| Variable | Comparing Outcomes after Transplanting HCV-Viremic Kidneys Versus HCV-Nonviremic Kidneys into HCV-Seronegative Recipients | Comparing Outcomes for Recipients of HCV-Viremic Kidneys When Transplanted into HCV-Seronegative Versus HCV-Seropositive Recipientsa | ||||
|---|---|---|---|---|---|---|
| HCV NAT D+/R−, n=103 | Matched Comparators HCV NAT D−/R−, n=206 | P Valueb | HCV NAT D+/R−, n=102 | Matched Comparators HCV NAT D+/R+, n=204 | P Valueb | |
| Delayed graft function, N (%) | 20 (19.6%) | 22 (11%) | 0.05 | 20 (19.9%) | 33 (16.4%) | 0.44 |
| Acute rejection, N (%) | 4 (3.9%) | 11 (5.4%) | 0.57 | 4 (3.9%) | 13 (6.3%) | 0.38 |
| Graft failed but recipient alive, N (%) | 0 (0%) | 0 (0%) | — | 0 (0%) | 0 (0%) | — |
| Died, N (%) | 0 (0%) | 6 (2.9%) | — | 0 (0%) | 7 (3.4%) | — |
| No. analyzedc | n=101 | n=190 | n=100 | n=193 | ||
| 6-mo creatinine, mg/dl, mean (SD) | 1.26 (0.31) | 1.27 (0.36) | 0.73 | 1.26 (0.31) | 1.22 (0.39) | <0.01 |
| 6-mo eGFR, ml/min per 1.73 m2, mean (SD) | 66.3 (17.4) | 66.4 (17.5) | 0.41 | 66.4 (17.4) | 70.1 (17.7) | 0.02 |
| No. analyzedd | n=93 | n=173 | n=94 | n=173 | ||
| 12-mo creatinine, mg/dl, mean (SD) | 1.26 (0.34) | 1.29 (0.49) | 0.33 | 1.26 (0.35) | 1.2 (0.37) | 0.01 |
| 12-mo eGFR, ml/min/1.73 m2, mean (SD) | 66.3 (18.7) | 67.1 (22.5) | 0.86 | 66.5 (18.8) | 71.1 (18.9) | 0.06 |
HCV, hepatitis C virus; NAT, nucleic acid test; —, P values were not computed.
We found matches for 102 of 103 patients.
P values were computed using STATA vanelteren test for continuous outcomes and conditional logistic regression for binary outcomes. Due to low anticipated event rate we did not compute P values for the following variables: graft failed but recipient alive; and died.
Pairs were excluded from analysis when patients did not have 6-month creatinine values; also, pairs were excluded in which two of two comparators lacked 6-month follow-up creatinine.
Pairs were excluded from analysis when patients did not have 12-month creatinine values; also, pairs were excluded in which two of two comparators lacked 12-month follow-up creatinine.