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. 2019 Jul 11;30(10):1870–1885. doi: 10.1681/ASN.2018101067

Figure 1.

Figure 1.

Pre-IRI therapy with Bregs attenuated acute renal injury after renal IRI. (A) Tim-1+CD19+ Bregs sorted from CD45.1 mice were transferred to CD45.2 mice 1 day before IRI; mice were harvested 1 day after IRI. (B) Levels of serum creatinine and BUN at 1 day after IRI. (C) Renal tubular injury scores from periodic acid–Schiff staining on day 1. Original magnification, ×200. (D) Flow cytometry analysis of splenic Bregs and Tregs. (E) Flow cytometry analysis of renal leukocytes. Results were expressed as dot plots with the mean±SEM. n=3–9. *P<0.05, **P<0.01, compared with the PBS group. Bregs, regulatory B cells; IRI, ischemia-reperfusion injury; Tregs, regulatory T cells.