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. 2019 Jul 11;30(10):1870–1885. doi: 10.1681/ASN.2018101067

Figure 3.

Figure 3.

Anti-CD45RB with or without anti–Tim-1 treatment before IRI attenuated acute renal injury after renal IRI. (A) Anti-CD45RB, anti-CD45RB with anti–Tim-1 or PBS was administered to WT mice 1 day before IRI; mice were harvested on days 1 and 3 after IRI. (B) Levels of serum creatinine and BUN after IRI. (C) Flow cytometry analysis of splenic Bregs and Tregs after IRI. (D) Flow cytometry analysis of renal leukocytes, Bregs, and Tregs after IRI. Results were expressed as dot plots with the mean±SEM. n=3–9. *P<0.05, **P<0.01, compared with the PBS group. #P<0.05, anti-CD45RB group compared with the anti-CD45RB/anti–Tim-1 group. Bregs, regulatory B cells; IRI, ischemia-reperfusion injury; Tregs, regulatory T cells; WT, wild type.