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. 2019 Jul 11;30(10):1870–1885. doi: 10.1681/ASN.2018101067

Figure 8.

Figure 8.

Reno-protective effects of anti-CD45RB treatment against IRI were dependent on IL-10+ regulatory B cells. (A) B cells sorted from IL-10 KO mice were transferred to RAG1 KO mice 2 weeks before IRI. Anti-CD45RB or PBS was administered to RAG1 KO mice with transferred IL-10–deficient B cells 1 day before IRI; mice were harvested on 1 day after IRI. (B) Levels of serum creatinine and BUN. (C) Flow cytometry analysis of splenic and renal Bregs. Results were expressed as dot plots with the mean±SEM. n=6. Bregs, regulatory B cells; IRI, ischemia-reperfusion injury; KO, knockout; RAG1, recombination activating gene 1; Tregs, regulatory T cells.