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. 2019 Jul 11;16(10):1461–1470. doi: 10.1080/15476286.2019.1637696

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Figure 4. — SIRT1 was an immediate target of miR-138.

(a) The bioinformatics software of TargetScan (http://www.targetscan.org/) was adopted to predicate the target gene of miR-138. (b) The relevance between miR-138 and SIRT1 was estimated by Dual-Luciferase reporter assay. After transfection with miR-138 mimic, inhibitor and the correlated negative controls (NC and NC inhibitor), (c) the mRNA and (d) protein levels of SIRT1 were appraised by RT-qPCR and western blot assays. **, P < 0.01, ***, P < 0.001.