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PI3K/AKT and AMPK pathways affected the functions of SAL and miR-138 in ARPE-19 cell viability and ROS generation.
ARPE-19 cells were transfected with miR-138 mimic and co-disposed with HG (50 mM) and SAL (3 μM). After administration with PI3K/AKT activator (IGF-1) and AMPK activator (AICAR), (a) cell viability and (b) ROS generation were evaluated by CCK-8 and DCFH-DA molecular probe assays. *, P < 0.05, ***, P < 0.001.
