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Regnase-1 is required for remodelling miRNA profile during the larva-to-pupa transition.
(a-b) Abundance of top five miRNAs that are significantly (a) upregulated and (b) downregulated in regnase-1-/- early pupae compared with control early pupae, determined by high-throughput sequencing. Mean ± SD for three biological replicates. P-value <0.05 is indicated by *. Third instar larvae are shown as ‘Larvae’ for simplicity.
