Figure 2.

Types of multivalent interactions driven by modular domains in LLPS systems. A, interaction network of N-WASP, nephrin, and NCK. B, schematic representations showing the network of multivalent interactions involving major PSD proteins. Solid line indicates direct modular domain interactions. Dashed line indicates indirect recruitment of actin filaments via Shank3 and Homer proteins. C, schematic interaction network of presynaptic active-zone proteins RIM and RIM-binding protein together with the cytoplasmic tail of the N-type voltage-gated Ca²⁺ channel (NCav).