Table 1.
Proteins involved in the proposed vesicular transport
All proteins have been reported in proteomic studies of chicken eggshell (ES) or uterine fluid (UF) (11, 15, 19, 21). ANX and CA can provide Ca2+ or HCO3−, respectively. ACC can be stabilized by LYZ (103), OC17 (105), or OVAL (104). EV markers are from the Vesiclepedia database (106).
| Mineralizing activity |
EV markers found in ES or UF |
|||
|---|---|---|---|---|
| Targeting | Ion accumulation (Ca2+ and HCO3−) | ACC stabilization | Function | Protein symbol |
| EDIL3 | ANXA1 | LYZ | Chaperone | HSP90AA1 |
| MFGE8 | ANXA2 | OC17 | HSP90B1 | |
| ANXA5 | OVAL | HSPA5 | ||
| ANXA8 | HSPA8 | |||
| CA2 | Biogenesis factor | PDCD6IP | ||
| CA4 | Syntenin-1 | |||
| EZR | ||||
| TSG101 | ||||
| Cell adhesion | FN1 | |||
| Intracellular trafficking | RAB10 | |||
| Membrane organiszer | CD9 | |||
| Signaling protein | YWHAE | |||
| YWHAZ | ||||
| Other (cargo) | ALB | |||
| VCP | ||||
| TPI1 | ||||
| GSN | ||||
| LDHB | ||||
| ENO1 | ||||
| GDI2 | ||||