Figure 2.

Overall crystal structure of GfTNMT in complex with SAH and SMS. A, single subunit of GfTNMT is drawn in ribbon representation colored along a gradient from the N terminus (blue) to the C terminus (red), with the portion of the structure that is poorly defined by electron density from residues 68 to 81 being represented by a dashed line. SAH (carbon atoms, magenta) and SMS (carbon atoms, gray) are shown in all-atom, space-filling representation. Solvent-accessible surface in semi-transparent light gray is shown superimposed onto the ribbon diagram. B, homodimer of GfTNMT was constructed by applying a crystallographic 2-fold rotational symmetry operator on the asymmetric unit composed of a single protomer.