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. Author manuscript; available in PMC: 2020 Jan 17.
Published in final edited form as: Nature. 2019 Jul 17;572(7769):335–340. doi: 10.1038/s41586-019-1406-x

Figure 1. LMNA mutation causes arrhythmic phenotype in patient specific iPSC-CMs.

Figure 1.

a, Quantification of arrhythmic occurrence in control and mutant iPSC-CMs. b, Schematic view of genome editing strategy. c, Quantification of arrhythmic occurrence in isogenic iPSC-CMs. d-g, Electrophysiological measurements of spontaneous action potentials in parental mutant iPSC-CMs (III-3; WT/MT), isogenic mutant iPSC-CMs (III-3; Del-KO/MT), isogenic control iPSC-CMs (III-3; WT/Cor-WT), and control iPSC-CMs (IV-2; WT/WT). The experiments were repeated three times independently with similar results.