. Author manuscript; available in PMC: 2020 Oct 1.

Published in final edited form as: Alcohol Clin Exp Res. 2019 Aug 26;43(10):2100–2110. doi: 10.1111/acer.14157

Table 2.

Most Predictive P-value Thresholds for Each PRS

		African ancestry sample					European ancestry sample
Predictor	P-value threshold	β	SE	p	R²_full	ΔR²_{full-baseline}	β	SE	p	R²_full	ΔR²_{full-baseline}
DPW-PRS	p <.0001	0.049	0.044	.269	.071	.002	0.019	0.026	.462	.056	.000
	p <.001	0.029	0.044	.517	.069	.000	0.022	0.027	.424	.056	.000
	p <.01	0.009	0.036	.800	.069	.000	0.044	0.026	.091	.058	.002
	p <.05	−0.022	0.036	.536	.069	.000	0.069	0.025	.006	.061	.005
	p <.10	−0.040	0.037	.276	.070	.001	0.069	0.025	.005	.061	.005
	p <.20	−0.020	0.040	.612	.069	.000	0.080	0.025	.001	.062	.006
	p <.30	−0.018	0.041	.664	.069	.000	0.078	0.024	.001	.062	.006
	p <.40	−0.021	0.041	.601	.069	.000	0.078	0.024	.001	.062	.006
	p <.50	−0.018	0.040	.662	.069	.000	0.076	0.024	.002	.062	.006
RISK-PRS	p <.0001	0.015	0.037	.685	.069	.000	0.072	0.027	.009	.061	.005
	p <.001	0.063	0.047	.179	.071	.002	0.073	0.028	.008	.061	.005
	p <.01	−0.051	0.051	.316	.070	.001	0.098	0.026	<.001	.065	.009
	p <.05	−0.044	0.041	.283	.070	.001	0.106	0.026	<.001	.067	.011
	p <.10	−0.067	0.036	.066	.073	.004	0.114	0.026	<.001	.069	.013
	p <.20	−0.088	0.044	.045	.075	.006	0.112	0.026	<.001	.068	.012
	p <.30	−0.078	0.047	.094	.074	.005	0.110	0.026	<.001	.068	.012
	p <.40	−0.071	0.047	.129	.073	.004	0.112	0.026	<.001	.068	.012
	p <.50	−0.068	0.046	.138	.073	.004	0.112	0.026	<.001	.068	.012

Note. DPW = drinks per week, RISK = first principal component of risky behaviors. Bolded are the most predictive p-value thresholds for each PRS. ΔR²_{full-baseline} refers to a change in R² when specific PRS score was added to the baseline model, which included sex, age, their interaction term and 10 PCs.