Figure 4. Delivery of additional high-frequency stimuli overcomes the deficit in long-term potentiation following prenatal ethanol exposure in both sexes.

(A) Average long-term potentiation (LTP) recordings from the beginning of baseline to the end of the post-conditioning recording. Dots represent the average percentage of change in the field excitatory postsynaptic potential (fEPSP) slope relative to baseline and the error bars represent the SEM. The arrow indicates the delivery of 2 bouts of high-frequency stimulation (B) LTP was measured as the average percentage of change in the fEPSP slope relative to baseline for minutes 55-60 following delivery of the 2xHFS. The delivery of additional HFS restored the magnitude of LTP to control levels (as indicated by the dashed grey bar in B). Bars represent the average percentage of change in the fEPSP slope for and LTP with points representing the average LTP for each individual slice in this dataset. Experimental n: LTP_{EtOH Female 1xHFS}: 29.67 ± 7.66 %; n = 11 slices, 5 animals, 3 litters; LTP_{EtOH Female 2xHFS}: 63.59 ± 7.92 %; n = 16 slices, 5 animals, 2 litters; LTP_{EtOH Male 1xHFS}: 34.89 ± 7.98 %; n = 8 slices, 5 animals, 3 litters; LTP_{EtOH Male 2xHFS}: 94.76 ± 12.43 %; n = 13 slices, 7 animals, 3 litters. * p < 0.05.