Figure 5. Prenatal ethanol exposed male offspring exhibit reduced long-term depression.

(A) Dots represent the average percentage of change in the field excitatory postsynaptic potential (fEPSP) slope relative to baseline and the error bars represent the SEM. Representative traces for each group are indicated above with 1 indicating the average fEPSP at baseline and 2 indicating the average fEPSP at the end of the post-conditioning recording. (B) Short-term depression (STD) is measured as the percentage of change in the fEPSP slope for the first minute immediately following the low-frequency stimulation (LFS; 900×1Hz) and is unaffected by PNEE. (C) LTD was measured as the average percentage of change in the fEPSP slope relative to baseline for minutes 55-60 following delivery of the LFS (indicated as black bar in A). The magnitude of LTD was reduced only in male offspring following PNEE. Bars represent the average percentage of change in the fEPSP slope for STD (B) and LTD (C) with points representing the average PTP and LTP for each individual slice in this dataset. Experimental n: LTD_{Control Female}: −28.46 ± 3.56 %; n = 14 slices, 6 animals, 2 litters; LTD_{PNEE Female}: −27.90 ± 5.46 %; n = 9 slices, 7 animals, 3 litters; LTD_{Control Male}: −24.89 ± 4.76 %; n = 12 slices, 5 animals, 2 litters; LTD_{PNEE Male}: −10.83 ± 3.33 %; n = 11 slices, 5 animals, 3 litters * p < 0.05.