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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Trends Neurosci. 2019 Sep 5;42(10):693–708. doi: 10.1016/j.tins.2019.08.005

Figure 1: Interactions driving MLO formation.

Figure 1:

Many different types of interactions have been shown to drive or contribute to LLPS and MLO formation. These include RNA-RNA, protein-RNA (through RNA-RNA binding domain (RBD) interactions or RNA-IDR/IDP interactions), and different kinds of protein-protein interactions, like self-interactions between IDRs or interactions between an IDP and structured protein. Granule components exchange with the surrounding environment, from the dilute phase to the condensed phase. Within the granule, RNA and protein molecules both form multivalent interactions, meaning that one molecule can interact with multiple others simultaneously.