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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Trends Endocrinol Metab. 2019 Aug 16;30(10):710–723. doi: 10.1016/j.tem.2019.07.020

Figure 2. Crosstalk between peroxisomes and mitochondria in the regulation of mitochondrial dynamics and thermogenesis.

Figure 2.

Cold promotes peroxisomal biogenesis in brown and beige fat through activation of the thermogenic co-regulatory protein PRDM16. Peroxisomes are required for synthesis of plasmalogens, ether-linked phosphophlipids, which are present in mitochondria. Plasmalogens are necessary for mitochondria to undergo cold-induced fission, presumably due to their effects on recruitment and/or activity of fission factors, such as Drp1. Mitochondrial fission is linked to increased thermogenic activity. This figure was created using  BioRender (https://biorender.com/).