Corry 1998.

Methods	Method of randomisation: 1 of 20 cards containing the instruction BoNT‐A or cast was drawn for each participant. Randomisation was restricted to ensure 10 participants in each group. Blinding: no blinding of participants and personnel providing treatment. The surgeon assessing the postintervention gait videotapes was blinded to the treatment received. Intention‐to‐treat analysis: no Loss of follow‐up: no Unit of analysis: lower limb
Participants	Place: 1 centre in Ireland Period of study: not described Number assigned: 20 Number assessed: 20 10 BoNT‐A group 10 control group Inclusion criteria: Children with CP Dynamic component to calf equinus Exclusion criteria: Children were excluded if their body weight was under 10 kg or there was a medical contraindication to BoNT‐A Study entry was delayed to ensure that no BoNT‐A injections or orthopaedic surgery had occurred within 6 months or change to oral or other antiplasticity treatment (e.g. intrathecal baclofen) within 2 months of study commencement Age: Both groups (mean/range): 4.6/2 to 9 years Gender: Males: 13 participants Females: 7 participants Motor distribution: Both groups: 8 hemiplegia; 11 diplegia; 1 quadriplegia GMFCS: Not described
Interventions	BoNT‐A group: Single BoNT‐A injection into the calf muscles of onabotulinumtoxinA in 8 children (6 to 8 U/kg) and abobotulinumtoxinA in 2 children (15 U/kg) Control group: Serial casting
Outcomes	Length of follow‐up: Follow‐up of 12 weeks Assessments at baseline, 2 and 12 weeks Primary outcomes: Clinical examination (ankle range of motion and spasticity) Physician Rating Scale for gait 3‐dimensional gait analysis data (kinematics)
Notes	Comments: The study authors state: "Three patients in the BoNT‐A group and five patients in the Cast group were unsuitable for the Vicon system because of age/height/cooperation constraints". Source of funding: supported by The Royal Belfast Hospital for Sick Children, the Medical Research Council, the MITRE trust, the Canon Gribben Legacy, and the Helen C Young Trust Fund Conflicts of interest: not reported
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Comment: 1 of 20 cards containing instructions for BoNT‐A or cast was drawn for each child (10 cards for each group)
Allocation concealment (selection bias)	Low risk	Comment: adequate allocation concealment. Instructions written in identical, sealed envelopes.
Blinding of participants and personnel (performance bias) All outcomes	High risk	Comment: no blinding of participants and personnel providing treatment
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Comment: the surgeon assessing the postintervention gait videotapes was blinded to the treatment received
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Comment: gait analysis data were not available for 3 children in the BoNT‐A group and 5 children in the cast group, as described in the 'Notes' section above.
Selective reporting (reporting bias)	Unclear risk	Comment: study protocol not available. It appears that the relevant outcomes were addressed.
Other bias	Low risk	Comment: no other sources of bias identified