2.

肿瘤病人体液EV作为肿瘤诊断标志物

Body fluid EVs as diagnostic markersfor tumors

Tumor type	Molecues	Body fluid	Markers	Application	Reference
Prostate cancer	Protein	Urine	β-catenin	Screening	[44]
Prostate cancer	miRNA	Plasma, serum, urine	4 miRNAs	Diagnosis, prognosis	[45]
Prostate cancer	Vesicles	Plasma	Microvesicle number	Diagnosis, prognosis	[46]
Ovarian cancer	Protein	Serum	exosomal antigen	Diagnosis	[47]
Ovarian cancer	miRNA	Serum	12 miRNAs	Screening	[48]
Lung cancer	Protein	Pleural effusion	3 proteins	Diagnosis	[49]
Lung squamous cell carcinoma	miRNA	Plasma	5 miRNAs	Monitor	[50]
Lung adenocarcinoma cancer	miRNA	Plasma	10 miRNAs	Screening	[51]
GBM	miRNA	Serum	3 miRNAs	Diagnosis	[52]
Breast Cancer	miRNA	Serum	3 miRNAs	Diagnosis	[53]
Pancreatic cancer	mRNA	Saliva	7 mRNAs	Diagnosis	[54]
Colon cancer	Protein	Ascites	Claudin-3	Diagnosis	[55]
Melanoma	Protein	Plasma	Caveolin-1	Diagnosis, prognosis	[56]
Gastric cancer	Vesicle	Plasma	EVs concentration	Diagnosis	[57]
Bladder Cancer	Protein	Serum	EPS812, mucin-4	Diagnosis	[58]
Cervical cancer	miRNA	Cervical lavage fluid	miR-21, miR-146a	Diagnosis	[59]
Acute lymphoma	miRNA	Plasma	miR-92	Diagnosis	[60]
Liver cancer	Vesicles	Serum	Microvesicle number	Diagnosis	[61]