Table 3.

Associations between TH, outcome measures and coagulation parameters of infants with NE.

Haem variable		TH		NE Grade		Death
	D	Median	p	Median	p	Median	p
PT	1	17.5 (16.1–22.7), 13.9 (13–17.1)	<0.001	17.8 (16–22.7), 13.9 (13.2–16.6)	<0.001	53.9 (22.9–53.9)*, 16.7 (14–19.3)	0.007
	2	15.8 (14.3–20.3), 12.5 (11.4–13.4)	<0.001	15.3 (13.9–19.6), 12.5 (11.5–13.4)	<0.001	32.8 (22.6–32.8)*, 14.4 (12.5–16.1)	0.006
	3	16.1 (13.6–17.9), 10.9 (10.5–13.5)	<0.001	14.7 (13.4–17.6), 10.6 (10.1–10.9)	0.002	21.7 (15.9–21.7)*, 13.9 (12.4–17.4)	0.15
	7	N/A	N/A	11.5 (10.9–13.3), 11.4*	0.71	N/A	N/A
APTT	1	40.3 (34.8–46.6), 31.3 (27.3–35.6)	<0.001	39.4 (33.2–45.2), 31.4 (28.7–35.6)	<0.001	71.1 (45.6–71.1)*, 35.8 (31.2–40.7)	0.008
	2	37.8 (35.2–45.3), 30.9 (27.8–33.9)	<0.001	36 (33.2–42.6), 31 (28–34)	0.002	42.8 (41.9–42.8)*, 34.5 (31.1–38.1)	0.04
	3	41.7 (38–48.6), 29.1 (26.2–33.5)	<0.001	39.1 (34.4–45.8), 26.2 (25.1–28)	0.002	45.9 (43.9–45.9)*, 38 (32.2–44.3)	0.18
	7	N/A	N/A	30.1 (28.3–32), 31.5*	0.39	N/A	N/A
Fib	1	1.3 (1–1.7), 1.8 (1.4–2.1)	0.001	1.3 (1–2), 1.7 (1.4–2.1)	0.04	0.61 (0.27–0.61)*, 1.5 (1.2–2)	0.009
	2	2.1 (1.7–2.4), 2.5 (2.2–3.1)	0.007	2.1 (1.7–2.6), 2.5 (2.1–3.1)	0.05	1.9 (0.4–1.9)*, 2.2 (1.8–2.7)	0.07
	3	2.1 (2–3), 2.6 (1.8–3.2)	0.59	2.2 (1.9–3), 2.8 (2.4–3.6)	0.15	2.0 (2–2)*, 2.4 (2.0–3.1)	0.23
	7	N/A	N/A	2.6 (2–3.3), 2.8*	0.71	N/A	N/A

Medians (IQR) of cooled vs. non-cooled infants, abnormal vs. normal NE grade and death vs. survival, followed by a p-value (p); D, Day; PT, Prothrombin Time (secs); APTT, Activated Partial Thromboplastin Time (secs); Fib, Fibrinogen (g/L); N/S, Not significant; N/A, Not applicable due to missing values;

^*No IQR available due to small numbers.