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. 2019 Oct 1;10:2296. doi: 10.3389/fimmu.2019.02296

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Copyright © 2019 Armstrong, Bording-Jorgensen, Chan and Wine.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Secretion of IL-18 and not IL-1β, is involved in bacterial killing. Raw264.7 cells or control J77 cells were treated as indicated and inoculated with C. rodentium (MOI = 1:10). Supernatants were collected and run on ELISA for (A) IL-1β and (B) IL-18. J77 cells were then transfected with siASC or scramble control and examined for secretion of (C) IL-1β and (D) IL-18. Samples were compared to non-infected control (NI) cells which received no treatment or infection. Values represent mean ± SEM between 3 independent experiments; *p < 0.05, **p < 0.01. YVAD (Ac-Tyr-Val-Ala-Asp-Chloromethylketone); MOI (multiplicity of infection).