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SLC-TREM-1 reduces endothelial cells activation. SLC-TREM-1 decreased endothelial cells cytokines/chemokines production induced by LPS as assessed by ELISA (A) or cytokines array (B) (two different experiments). It reduced LPS-induced ERK1/2 and p65 phosphorylation while increased p-eNOS (C). SLC-TREM-1 also decreased neutrophils transmigration across TNF-α activated endothelial cells (D). *p < 0.05, **p < 0.01, and ***p < 0.001 vs. activated cells.
