Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 1;10:2155. doi: 10.3389/fmicb.2019.02155

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Ashrafian, Shahriary, Behrouzi, Moradi, Keshavarz Azizi Raftar, Lari, Hadifar, Yaghoubfar, Ahmadi Badi, Khatami, Vaziri and Siadat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Morphologic characterization of EVs and impact of Akkermansia muciniphila and its EV administration on body and adipose weight, food intake, and blood parameters in both ND- and HFD-fed mice after 5 weeks (n = 5 for each group). (A) Illustration showing obesity induction and amelioration after treatment. (B) Scanning electron micrograph image of A. muciniphila-derived EVs. (C) Body weight gain per mouse. (D) Average daily food intake. (E) Epidydimal adipose weight (EAT). (F) Histopathology image. Scale bar is 50 μm. (G) Total cholesterol levels. (H) Triglyceride levels and (I) glucose levels. ^∗P < 0.05 and ^∗∗P < 0.01 were considered statistically significant, respectively. ND, normal diet + PBS; NA.m, normal diet + A. muciniphila (10⁹ CFU); NEV, normal diet + EVs (10 μg protein); HFD, high-fat diet + PBS; HA.m, high-fat diet + A. muciniphila (10⁹ CFU); HEV, high-fat diet + EVs (10 μg protein).