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. 2019 Oct 7;9:14363. doi: 10.1038/s41598-019-50915-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Random motility of endothelial cells on 2D substrates. (a) Representative cell trajectories observed in two parallel HUVEC cultures – transfected with control-siRNA (green) or Tks4-siRNA (red) – on fibronectin substrate are superimposed for comparison. Trajectories were extracted from 24 hours long time-lapse recordings, also see Supplementary Videos S1 and S2. (b) Time-dependent cell speeds on fibronectin, averaged over the tracked cells for each time point. (c) Average cell displacements on fibronectin during various time intervals. Data in (b and c) were collected from n = 145 control-si cells and n = 151 Tks4-si cells on fibronectin in two independent sets of experiments. (d) Time-dependent cell speeds on collagen I. (e) Average cell displacements on collagen I. Data in (d and e) were collected from n = 20 control-si cells and n = 20 Tks4-si cells on collagen I. Error stripes in graphs correspond to SEM.