Table 1.
Names and function of DDR genes evaluated by qRT-PCR in blood samples from RT patients.
| Gene symbol | Gene name | Function |
|---|---|---|
| ATM | Ataxia Telangiectasia Mutated | DNA damage signal transduction; cell cycle checkpoint |
| BAX | BCL2-associated X protein | Apoptosis |
| BBC3 | BCL2-binding component 3 (PUMA) | Apoptosis |
| BCL2 | B-Cell CLL/Lymphoma 2 | Apoptosis |
| CCNG1 | Cyclin G1 | Cell cycle progression/arrest |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21) | Cell cycle arrest |
| cMYC | MYC proto-oncogene, bHLH transcription factor | Cell cycle progression, apoptosis and cellular transformation |
| DDB2 | Damage-specific DNA binding protein 2 (p48) | DNA repair |
| FDXR | Ferrodoxin reductase | DNA damage, apoptosis |
| GADD45A | Growth arrest and DNA-damage-inducible, alpha | Growth arrest; DNA repair; apoptosis |
| MDM2 | Mdm2 p53 binding protein homolog | Inactivation of tumor protein p53 |
| PCNA | Proliferating cell nuclear antigen | DNA repair |
| SESN1 | Sestrin 1 (Sestrins) | Cell cycle arrest |
| XPC | Xeroderma pigmentosum, complementation group C | DNA repair |
| ZMAT3 | Zinc finger, matrin type 3 (PAG608) | Cell growth; apoptosis |