Table 3.

DDR genes associated with clinical variables of radiation toxicity.

Clinical variable	Gene	Gene expression valuea	Toxicity grade	Adjusted p-value	RT timing
Dermatitis radiation	FDXR	1.44	G2	0.096c	t1
		1.88	G3
Pain	SESN1	1.36	G0	0.043b	t1
		0.97	G1
	SESN1	1.36	Absent	0.020b	t1
		0.92	Present
Pruritus	XPC	1.49	G1	0.102c	t1
		0.79	G2
	ZMAT3	1.43	G0	0.046b	t1
		1.01	G1
	ATM	1.29	Absent	0.021b	t2
		0.87	Present
	BCL2/BAX	1.15	Absent	0.011b	t2
		0.76	Present
Fatigue	CDKN1A	1.42	G0	0.049b	t2
		1.19	G1

^aGene expression values are reported in irradiated relative to non-irradiated blood samples from RT patients and expressed in fold-change.

^bt-test;

^cWilcoxon test. Bonferroni adjusted p-value is significant when <0.05, moderately significant when <0.10.