Table 1.
Calicivirus proteins involved in translational control.
| Virus | Viral proteins | Cellular protein targets | Mechanisms | References |
|---|---|---|---|---|
| FCV MNV |
VPg | eIF3, eIF4F | Interacting with cellular factors and usurp the host protein synthesis machinery | (31, 33, 34, 36) |
| FCV | NS6/7 protease/polymerase | eIF4G | Processing translation factors and inhibiting global cellular protein synthesis | (118) |
| FCVMNV | NS6/7 and NS6 proteases |
PABP | Reduction in the translation of induced interferon stimulated genes (ISGs) | (64, 117) |
| MNV | eIF4E phosphorylation | Affecting translational state of specific host mRNAs | (119) | |
| FCV | NS6/7 protease/polymerase | G3BP1 and G3BP2 | Impairs formation of stress granules | (122) |
| MNV | G3BP1 | Impairs formation of stress granules | (123) |