Table 2.
Calicivirus factors involved in the modulation of the immune response.
| Genes | Virus | Viral factors | Immune regulatory functions | References |
|---|---|---|---|---|
| Norovirus | MNV | Virulence factor 1 | Downregulation of the IFN immune response | (41) |
| NS3 | Reduction of the MHC-I protein in the cell surface Decrease in viral antigen presentation Altered CD8+ T cells response |
(111) | ||
| Unknown | NO reduction by COX2/PGE2 pathway activation | (138) | ||
| NS1/2 | Impairment of IFN III pathway | (115) | ||
| VP2 | Regulation of antigen presentation | (133, 134) | ||
| HuNoV MNV |
NS4(p22) NS4 (p18) |
Impairment of INF and cytokine signaling | (56) | |
| Vesivirus | FCV | dsRNA | Induction of IFN-b promoter by FCV strain 2280 Lack of IFN-b induction by FCV strains F9, Bolin ad HRB-SS |
(84) |
| NS3 (p39) | Downregulation of Interferon 1 pathway by preventing IRF-3 activation | (106) | ||
| NS6/7 | Sgs assembly disruption by G3BP-1 and G3BP-2 cleavage | (122) | ||
| Unknown | NO reduction by COX2/PGE2 pathway activation | (138) | ||
| Sapovirus | PSaV | VPg and NS6/7 | NO reduction by COX2/PGE2 pathway activation | (137) |