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. 2019 Oct 1;10:1110. doi: 10.3389/fphar.2019.01110

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Copyright © 2019 Nie, Xia, Liu, Zhou, Ye, Hean, Meng, Liu, Liu, Wen, Ren, Chen and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association between Wnt3 messenger RNA (mRNA) levels and various clinicopathological factors of colorectal cancer (CRC) patients. (A) Wnt3 mRNA levels of CRC tumor tissues in stage II and III. (*P < 0.05). (B) Wnt3 mRNA levels in CRC patients with different age, drinking history, and fecal occult blood test (FOBT) (N = 46, *P < 0.05). (C1–C2) Wnt3 mRNA levels in CRC patients with different gender and smoking history (N = 46, *P<0.05). (C3–C5) Wnt3 mRNA levels of CRC tumor tissues in TNM stages are shown (*P < 0.05). (C6–C10) The association between Wnt3 mRNA levels and level of alanine transaminase (ALT), aspartate aminotransferase (AST), albumin (ALB), creatinine (CREA), and urea levels in CRC patients (N = 46). (D) The overall survival curve of CRC patients (N = 279) according to Wnt3 mRNA level were analyzed with data from the TCGA.