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. 2019 Oct 1;10:1224. doi: 10.3389/fphys.2019.01224

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Copyright © 2019 Wang, Zhao, Ajay, Jiao, Zhang, Wang, Gao, Yuan, Liu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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QDTS granules reduced 12 h UAE of db/db mice effectively and safely. (A–C) Describe changes in 12 h UAE, fasting blood glucose, and random blood glucose during drug intervention, respectively (detected once every 2 weeks). (D,E) Show the effects on body weight and the ratio of kidney weight to body weight. (F,G) Showed that QDTS did not cause liver and kidney dysfunction. ALT increased in db/db mice, which might be related to fatty liver. ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001: Compared with the model group, respectively; ^###p < 0.001: compared with the normal control group.