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. 2019 Oct 1;10:1224. doi: 10.3389/fphys.2019.01224

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Copyright © 2019 Wang, Zhao, Ajay, Jiao, Zhang, Wang, Gao, Yuan, Liu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Renal autophagy| activity of db/db mice was activated by QDTS. (A–D) Are the expression of Atg14, Beclin1, LC3-II, and p62, respectively; (E) is the staining result (400x) of LC3-II immunofluorescence of paraffin sections. The small soft highlights in the figure are the specific expression of LC3-II, which was blindly reviewed and given a score by three pathologists, according to the quantity from least to greatest (score 0–5) divided into five levels. The results of evaluation are shown in (F). ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001: Compared with the model group, respectively; ^##p < 0.01 and ^###p < 0.001: compared with the normal control group, respectively.