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. 2019 Oct 1;7:238. doi: 10.3389/fbioe.2019.00238

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Copyright © 2019 Li, Mao, Chen, Li, Wang and Mo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Calixarene cone formation creates a bowl-shaped cavity for CPT and an internal core for PTX, giving rise to a dual-loaded nanoparticle (PTX-CPT-P4C6).