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. 2019 Oct 1;10:2319. doi: 10.3389/fimmu.2019.02319

Table 2.

Comparison of patients and transplant characteristics according to pre-HSCT IL6 levels.

Pre-HSCT IL6
<2.5 pg/mL
(n = 111)
Pre-HSCT IL6
≥2.5 pg/mL
(n = 55)
p
Patient age y, median (range) 48 (15-76) 50 (22-77) 0.17
Patient sex, male 66 39 0.17
HCT-CI, median (range) 2 (0–7) 3 (0–7) 0.02
Type of diagnosis, n 0.53
Acute leukemia 69 35
MDS or MPN 22 7
Lymphoma or MM 19 12
other 1 1
DRI at HSCT, n <0.01
Low or intermediate 60 14
High 45 29
Very high 6 12
Conditioning, n 0.49
RIC 17 6
MAC 94 49
Type of donor, n 0.19
MRD 26 10
MUD 31 10
MMRD 54 35
Stem cell source, n 0.78
PBSC 100 51
BM 11 4
H/D CMV status, n 0.94
Neg/neg 8 3
Neg/pos 5 3
Pos/neg 23 10
Pos/pos 75 39

HSCT, Hematopoietic stem cell transplantation; HCT-CI, hematopoietic cell transplantation-comorbidity index; MDS, myelodysplastic syndromes; MPN, myeloproliferative neoplasms; MM, multiple myeloma; DRI, Disease Risk Index; MAC, myeloablativeconditioning; RIC, reduced-intensity conditioning; MMRD, mismatched related donor; MRD, matched related donor; MUD, matched unrelated donor; PBSC, peripheral blood stem cells; BM, bone marrow; H/D, host/donor; CMV, cytomegalovirus.