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. 2019 Oct 7;9:249. doi: 10.1038/s41398-019-0586-3

Fig. 1. Significant loci associated with alcohol dependence in Han Chinese.

Fig. 1

a Manhattan plot for the discovery cohort. Red line denotes the threshold for P < 5 × 10−8. b and c: the regional plots for the two significant loci plotted using LocusZoom. The lead SNPs and functional SNPs after imputation are marked in the plot. b the locus located in 4q23 region with 230 SNPs with P < 5 × 10−8. The top index SNP was rs2075633 on ADH (P = 6.375 × 10−15). The nonsynonymous SNP rs1229984 was also present in this locus (P = 1.03 × 10−12). c the significant locus located in 12q24.12-12q24.13, with 5 SNPs with P < 5 × 10−8. The top index SNP was BRAP rs11066001 (P = 1.28 × 10−8) and the nonsynonymous SNP was ALDH2 rs671 (P = 3.98 × 10−8)