Table 3.
Association between the two functional AD SNPs with AD characteristics and BIS in the discovery cohort
| phenotype | samples | mean (SD) | CHR | SNP | A1 | BETA | SE | P |
|---|---|---|---|---|---|---|---|---|
| MAST | 435 | 10.25 (5.11) | 4 | rs1229984 | C | 1.514 | 0.3743 | 6.75 × 10−5 |
| 12 | rs671 | A | −1.776 | 0.9548 | 0.064 | |||
| BIS Sum | 426 | 34.36 (19.81) | 4 | rs1229984 | C | 3.956 | 1.427 | 5.93 × 10−3 |
| 12 | rs671 | A | 6.765 | 3.627 | 0.063 | |||
| Age onset of regular drink (year) | 409 | 22.72 (7.03) | 4 | rs1229984 | C | −0.9016 | 0.544 | 0.0986 |
| 12 | rs671 | A | 2.443 | 1.307 | 0.06254 | |||
| Duration of AD (year) | 400 | 22.85 (10.25) | 4 | rs1229984 | C | 0.7295 | 0.524 | 0.165 |
| 12 | rs671 | A | −2.542 | 1.261 | 0.04458 | |||
| Usual daily drink (standard drinks) | 380 | 7.69 (6.91) | 4 | rs1229984 | C | 2.087 | 0.5012 | 4.34 × 10−5 |
| 12 | rs671 | A | −0.8712 | 1.534 | 0.5704 | |||
| Maximum daily drinking (standard drinks) | 208 | 10.10 (8.81) | 4 | rs1229984 | C | 0.9966 | 0.9762 | 0.3092 |
| 12 | rs671 | A | 1.538 | 2.525 | 0.5434 |
MAST the Michigan Alcoholism Screening Test, BIS Barratt Impulsiveness Scale 11th version, SD standard deviation, SE standard error
To adjust for multiple testing, we applied the Bonferroni correction P value < 0.0083 (p < 0.05/6)