Fig. 4. Performance of the CSF sncRNA signature in classifying patients on the basis of postmortem brain tissue.

a Demographic information for postmortem brain tissue samples included in the analysis (published dataset GSE48552). b The six sncRNA signatures defined via the analysis of the signature cohort were tested on the data obtained from postmortem brain tissue (published brain cohort). ROC reveals a mean AUC of 0.89 suggesting that the sncRNA signature obtained from CSF helps to diagnose AD patients based on sncRNA expression in postmortem brain tissue. c Upper panel shows the confirmed target genes of the three miRNAs that are part of our sncRNA signature. Lower panel shows the significantly enriched signaling pathways based on the confirmed targets of the three miRNAs that are a part of the sncRNA signature. Error bars indicate SD