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. 2019 Oct 7;9:14375. doi: 10.1038/s41598-019-50884-9

Figure 1.

Figure 1

Antiproliferative effect of YM155 alone and in combination with TPGS in breast cell lines. (A) Chemical structures of YM155 and TPGS. (B) MTT assay was employed for the cytotoxicity evaluation (% cell viability) of increasing concentrations of YM155 (1, 5 and 10 nM) with or without 5 μΜ TPGS for 48 hours in SKBR3, MDA-MB-231, MCF-7, MDA-MB-361 and MCF-10A cells. IC50 of YM155 and TPGS as well the Combination Index (CI) in each cell line are shown in Table 1. (C) YM155 and TPGS effects on the mRNA and protein levels of Survivin at 48 hours of treatment (the blots were cropped; full length blots are shown in Fig. S6). The results represent the mean ± SEM of three different replicates and are representative of at least three different experiments. *P value < 0.05, **P value < 0.01, ***P value < 0.001.