Table 3.
Predictors of Heart failure hospitalization as determined via univariate and multivariate Cox proportional hazards regression analyses.
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Hazard ratios (95% CI) | p value | Hazard ratios (95% CI) | p value | |
| Male sex | 1.276 (0.875–1.859) | 0.205 | ||
| Age | 1.068 (1.044–1.091) | <0.001 | 1.052(1.027–1.077) | <0.001 |
| Hypertension | 1.124 (0.752–1.679) | 0.568 | ||
| Diabetes | 1.729 (1.158–2.581) | 0.007 | 1.144 (0.743–1.760) | 0.542 |
| Hyperlipidemia | 1.622 (1.115–2.360) | 0.011 | 1.524 (1.040–2.234) | 0.031 |
| NYHA classification | 0.896 (0.612–1.314) | 0.575 | ||
| Body mass index (kg/m2) | 0.958 (0.907–1.012) | 0.128 | ||
| Creatinine clearance (ml/min) | 0.941 (0.922–0.960) | <0.001 | 0.949 (0.930–0.969) | <0.001 |
| Δ ePVS | 1.007 (1.003–1.011) | <0.001 | 1.005 (1.001–1.010) | 0.024 |
| Baseline ePVS | 1.292 (1.092–1.528) | 0.003 | 1.305 (1.084–1.571) | 0.005 |
| LVEF | 0.981 (0.973–1.024) | 0.387 | ||
p-values were derived from Cox regression analysis.
Abbreviations: CI = confidence interval; ePVS = estimated plasma volume (Strauss formula); LVEF = left ventricle ejection fraction.