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. 2019 Oct 7;9:14394. doi: 10.1038/s41598-019-50840-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose response curves of cisplatin (CDDP) and bortezomib (BTZ) in NSCLC cell lines and immortal bronchial epithelial cells (Beas-2B) differing in endogenous and drug-induced levels of HSPA proteins expression. (A) Graphical representation of cell viability following 72 h treatment with CDDP measured by MTS assay (for each dose three independent repeats were performed, each in triplicate). (B) The basal expression of HSPA1, HSPA2, HSPA5, HSPA8 and HSPC protein. Representative immunoblots are shown (n = 3), actin is used as a protein loading control. (C) Graphical representation of cell viability following 72 h treatment with various concentrations of BTZ measured by MTS assay (for each dose at least three independent repeats were performed, each in triplicate). (D,E) Expression of HSPA proteins in cells exposed to CDDP (D) or BTZ (E) for 24 h. Representative immunoblots are shown (n = 4), actin was used as a protein loading control.