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. 2019 Oct 7;9:14362. doi: 10.1038/s41598-019-50692-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of NF449 on retrograde transport of Shiga toxin 1B. HeLa cells transfected with the ER-anchored SNAP-tag were treated with NF449 (n = 6), the Ca²⁺ chelator BAPTA-AM (n = 3) or PBS vehicle (n = 3) followed by Shiga toxin (Stx) 1B-subunit:O⁶-benzylguanine. No difference in Stx1B localization to the ER could be seen between NF449-treated and PBS-treated cells. Data is shown as median absorbance values (OD₄₉₀) from SNAP-captured Stx1B. The median is depicted by the bar. *P < 0.05, n.s.: non-significant, Kruskal-Wallis test.