Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 7;7(19):e14250. doi: 10.14814/phy2.14250

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Ability of PKD1 to potentiate insulin secretion positively correlates with stimulation index and BMI of humans. (A) At right, we confirm the expression of transcript encoding PKD1 (PKRD1) in human islets, and at left we measure insulin secretion in (ng/islet/hr) in 1‐h static incubations in response to 1 and 10 mmol/L glucose in the presence of PKD1 inhibitor, CRT0066101 (10 μmol/L). (B) Comparison of donor–donor response according to percentage inhibition of insulin secretion by PKD1 antagonist. (C–E) The percentage inhibition of responders after 20 min CRT0066101 treatment plotted against stimulation index (panel C; n = 13 donors), age (panel D; n = 13 donors), and BMI (kg/m²; panel E; n = 13 donors) in nondiabetic human islet donors. (F) Comparison of percentage inhibition by MRS2500 according to BMI tertiles (lean < 25; overweight 25–30; and obese> 35 kg/m²) (n = 5, 4, 4 donors).