Table 1.

Cox regression analysis for the occurrence of major adverse cardiovascular events

Variable	Unadjusted HR (95% CI)	P	Adjusted HR (95% CI)	P
Age	1.062 (1.038–1.086)	<0.001	1.052 (1.026–1.080)	<0.001
Male sex	0.609 (0.383–0.968)	0.036	1.006 (0.586–1.726)	0.984
Hypertension	2.209 (1.099–4.441)	0.026	1.384 (0.674–2.84)	0.376
Diabetes mellitus	2.015 (1.269–3.200)	0.003	1.738 (1.079–2.801)	0.023
Hyperlipidemia	1.105 (0.654–1.867)	0.708	-	-
Current smoking	0.670 (0.374–1.201)	0.179	-	-
Atrial fibrillation	1.064 (0.617–1.834)	0.824	-	-
Coronary artery disease	0.775 (0.450–1.335)	0.358	-	-
Initial NIHSS score	1.064 (1.031–1.098)	<0.001	1.068 (1.034–1.104)	<0.001
Hemoglobin	0.794 (0.699–0.901)	<0.001	0.870 (0.733–1.032)	<0.001
Creatinine	1.023 (0.851–1.229)	0.811	1.025 (0.841–1.250)	0.804
Total cholesterol	0.996 (0.991–1.002)	0.177	1.003 (0.997–1.009)	0.297
TMAO cut off	1.772 (1.111–2.826)	0.016	1.690 (1.030–2.771)	0.038

HR, hazard ratio; CI, confidence interval; NIHSS, National Institutes of Health Stroke Scale; TMAO, trimethylamine N-oxide.