Table 2.
IC50 values of MilIA and isoforms acting on different nAChR subtypes. The corresponding Hill coefficients are summarized in Table S1.
| IC50 | α1β1δε (nM) |
α1β1γδ (nM) |
α2β4 (nM) |
α4β2 (nM) |
α4β4 (nM) |
α7 (nM) |
α9α10 (nM) |
|---|---|---|---|---|---|---|---|
| MilIA | 11,180 ± 78,891 | 13,130 ± 1125 | >104 | >104 | >104 | >104 | >104 |
| MilIA [M9G] | >105 | 577 ± 79 | >104 | >104 | >104 | >104 | >104 |
| MilIA [N10K] | >105 | 3842 ± 148 | >104 | >104 | >104 | >104 | >104 |
| MilIA [∆1,M2R] | 19,550 ± 50 | 18,012 ± 1430 | >104 | >104 | >104 | >104 | >104 |
| MilIA [∆1,M2R, M9G, N10K, H11K] | 25 ± 1 | 16 ± 1 | >104 | >104 | >104 | >104 | 511 ± 195 |
| MilIA [M9G, N10K] | 149 ± 39 | 178 ± 57 | >104 | >104 | >104 | >104 | >104 |