Table 2.
Expression of representative Alzheimer’s disease-associated genes among the patients with severe OSA and non-severe OSA in descending order by probability.
| Gene Symbol | Expression | Log2(Fold Change) | Regulation | Probability | |
|---|---|---|---|---|---|
| Severe OSA | Non-Severe OSA | ||||
| Early-onset Alzheimer’s disease | |||||
| APP | 382.418 | 587.644 | −0.619 | Down | 0.503 |
| PSEN1 | 12.776 | 14.876 | −0.220 | Down | 0.286 |
| PSEN2 | 7.204 | 6.208 | 0.215 | Up | 0.265 |
| FKBP1B | 3.786 | 4.126 | −0.124 | Down | 0.216 |
| Late-onset Alzheimer’s disease | |||||
| CCL2 | 12.992 | 116.716 | −3.167 | Down | 0.868 a |
| IL6 | 2.854 | 33.06 | −3.534 | Down | 0.857 a |
| CXCL8 | 2.042 | 20.058 | −3.296 | Down | 0.824 a |
| HLA-A | 1.272 | 14.006 | −3.460 | Down | 0.811 a |
| IL1RN | 239.35 | 57.236 | 2.064 | Up | 0.806 a |
| CLU | 490.412 | 308.192 | 0.670 | Up | 0.522 |
| BIN1 | 23.218 | 18.884 | 0.298 | Up | 0.335 |
| APOE | 24.526 | 29.308 | −0.257 | Down | 0.318 |
| SORL1 | 8.136 | 9.338 | −0.199 | Down | 0.267 |
| PICALM | 56.394 | 52.512 | 0.103 | Up | 0.233 |
Abbreviations: OSA, obstructive sleep apnea. a Significantly up- and down-regulated genes were defined as false discovery rate (FDR) ≤ 0.001 (i.e., probability ≥ 0.8) and an absolute value of Log2Ratio ≥ 1.