. 2019 Sep 1;8(9):1361. doi: 10.3390/jcm8091361

Table 2.

Expression of representative Alzheimer’s disease-associated genes among the patients with severe OSA and non-severe OSA in descending order by probability.

Gene Symbol	Expression		Log₂(Fold Change)	Regulation	Probability
Gene Symbol	Severe OSA	Non-Severe OSA	Log₂(Fold Change)	Regulation	Probability
Early-onset Alzheimer’s disease
APP	382.418	587.644	−0.619	Down	0.503
PSEN1	12.776	14.876	−0.220	Down	0.286
PSEN2	7.204	6.208	0.215	Up	0.265
FKBP1B	3.786	4.126	−0.124	Down	0.216
Late-onset Alzheimer’s disease
CCL2	12.992	116.716	−3.167	Down	0.868 ^a
IL6	2.854	33.06	−3.534	Down	0.857 ^a
CXCL8	2.042	20.058	−3.296	Down	0.824 ^a
HLA-A	1.272	14.006	−3.460	Down	0.811 ^a
IL1RN	239.35	57.236	2.064	Up	0.806 ^a
CLU	490.412	308.192	0.670	Up	0.522
BIN1	23.218	18.884	0.298	Up	0.335
APOE	24.526	29.308	−0.257	Down	0.318
SORL1	8.136	9.338	−0.199	Down	0.267
PICALM	56.394	52.512	0.103	Up	0.233

Abbreviations: OSA, obstructive sleep apnea. ^a Significantly up- and down-regulated genes were defined as false discovery rate (FDR) ≤ 0.001 (i.e., probability ≥ 0.8) and an absolute value of Log₂Ratio ≥ 1.