Table 1.
Exhaled nitric oxide for the diagnosis of OSAS patients.
| First Author (Year) [Reference] | OSAS | AHI | NO | Device | FeNO ppb | HC | NO ppb | p-Value |
|---|---|---|---|---|---|---|---|---|
| Zhang (2018) [20] | 75 | 28.1 e/h | FeNO (1) | NIOX MINO® | (1) 21.08 (8.79) | 30 | (1) 16.9 (6.86) | 0.02 |
| nNO (2) | 50 mL/s | (2) 487 (115.8) | (2) 413 (73.1) | |||||
| Przybylowski (2006) [21] | 66 | 40.3 e/h | FeNO | CA 45−55 |
23.1 (14.8) | 53 | 16.8 (9.8) | <0.05 |
| Petrosyan (2008) [22] | 26 | 63.7 e/h | FeNO (1) | LR2000 CA 250 mL/s |
(1) 7.1 (4.6) | 9 O * 10NO † |
(1) 5 (1.1) * (1) 4.2 (1.9) (2) 366 (169) * (2) 539 (264) † (3) 4.8 (1) * (3) 4.7 (1.2) † |
<0.05 <0.05 <0.01 NS <0.05 <0.05 |
| nNO (2) | (2) 610 (222) | |||||||
| eCO (3) | (3) 6.4 (2.9) | |||||||
| Olopade (1997) [39] | 16 | 47.7 e/h | FeNO (1) | CA NA |
(1) 6.6 (0.8) | 8 | (1) 6.8 (1.3) | NA |
| nNO | ||||||||
| JalilMirmohammadi (2014) [29] | 31 O * | 39.5 e/h | FeNO | NObreath® | 14.1, 3–31 * | 7 | 22.1, 5–58 | NS |
| 16 NO † | 40.1 e/h | 50 mL/s | 15.8, 2–31 † | |||||
| Gut (2016) [41] | 28 | 6.6 e/h | nNO | Eco Medics AG | 867 (371) | 23 | 644 (166) | 0.047 |
| Fortuna (2011) [23] | 30 | NA | FeNO (1) | NIOX | (1) 27.2 (18) | 30 | (1) 16.7 (8) | 0.0006 |
| >15 e/h | CaNO (2) | 50 mL/s | ||||||
| Foresi (2007) [30] | 34 | 31.3 e/h | FeNO | NOA 280 50,120,190, 250 e 300 mL/s |
21.8 (1.9) | 9 | 15.4 (1.7) | NS |
| Duarte (2019) [26] | 199 | 30.1 e/h | FeNO | NIOX MINO® 50 mL/s |
20.2 (14.5) | 30 | 16.9 (10.6) | 0.221 |
| Depalo (2008) [33] | 18 O | 59.1 e/h | FeNO (1) | CA | (1) 23.1 (2.1) | 15 O * | (1) 17.9 (2.1) * | NS |
| iNOS (2) | 45 mL/s | 10NO † | (1) 7.2 (0.6) † | <0.001 | ||||
| Culla (2010) [32] | 39 | NA | FeNO (1) | CA | (1) 23.1, 19−28 | 26 AS * 15 CR † 24 ‡ |
(1) 40, 32−50 * (1) 22, 16−32 † (1) 11, 8−14 ‡ (2) 71, 56−91 * (2) 54, 40−73 † (2) 63, 59−73 ‡ |
NS NS <0.001 0.015 0.009 <0.001 |
| >10 e/h | oNO (2) | 50 mL/s | (2) 104, 80−135 | |||||
| Carpagnano (2008) [31] | 30 O | 59.1 e/h | FeNO | CA | 31.6 (1.6) | 20 O * | 27.1 (1.8) * | NS |
| 45 mL/s | 10 NO † | 4.8 (0.7) † | <0.001 | |||||
| Duong-Quoy (2015) [25] | 52 | 25.6 e/h | FeNO (1) | FeNO+ 50,100,150,350 mL/s |
(1) 16.7 (11.4) (2) 4 (1.7) |
30 | (1) 9.4 (6.6) | 0.003 |
| CaNO (2) | (2) 2.2 (0.7) | 0.001 | ||||||
| Barreto (2018) [28] | 17 CH mild * 17 CH mod/sev † |
2.3 e/h | FeNO | HyPair FENO | 11, 7.9−14.8 * | 20 | 13.5, 8.7−19.9 | NS |
| 8.6 e/h | 50 mL/s | 10, 6.5−16 † | ||||||
| Agustì (1999) [27] | 24 | 55 e/h | FeNO | CA | 22.2 (3) | 7 | 19.7 (3.2) | NS |
| NA | ||||||||
| Chua (2013) [24] | 75 | 40 e/h | FeNO | NIOX MINO® | 13.4 (6.5) | 29 | 6.5 (3.5) | <0.001 |
| 50 mL/s |
For those studies analyzing the change of FeNO during the night, the mean (SD) is that before the night. Legend: OSAS: obstructive sleep apnea syndrome; AHI: apnea-hypopnea index (e/h: events per hour); HC: healthy controls; FeNO: fractional exhaled nitric oxide; nNO: nasal nitric oxide; oNO: oral nitric oxide; O: obese; NO: not obese; CA: chemiluminenscence analyser; AS: asthma; CR: chronic rhinitis/rhinosinusitis. Symbols (*,†,‡) are used to link the value with the subgroup.