Table 1.
Demographic characteristics, comorbid conditions and prognostic scales in community-acquired pneumonia (CAP) according to organ failure.
| Organ Dysfunction | |||
|---|---|---|---|
|
n 52 (55.3) |
Yes 42 (44.7) |
p-Value | |
| Demographics | |||
| Age (years) | 60 (42–69) | 70 (56–78) | * 0.002 |
| Gender (male) | 32 (61.5) | 24 (57.1) | 0.666 |
| Pneumococcal vaccination | 1 (1.9) | 3 (7.1) | 0.213 |
| Influenza vaccination | 14 (26.9) | 16 (38.1) | 0.248 |
| Current smoker | 10 (19.2) | 10 (23.8) | 0.081 |
| Alcohol abuse (>80 g/day) | 2 (3.8) | 2 (4.8) | 0.179 |
| Prior antibiotic treatment (last month) | 22 (42.3) | 14 (33.3) | 0.374 |
| Comorbid condition | |||
| Diabetes mellitus | 3 (5.8) | 9 (21.4) | * 0.024 |
| Chronic liver disease | 0 (0) | 1 (2.4) | 0.263 |
| Heart disease | 13 (25) | 15 (35.7) | 0.259 |
| Renal disease | 2 (3.8) | 5 (11.9) | 0.139 |
| Neurological disease | 2 (3.8) | 5 (11.9) | 0.139 |
| COPD | 3 (5.8) | 15 (35.7) | * <0.001 |
| Charlson comorbidity index | 0 (0–1) | 1 (1–2) | * <0.001 |
| Prognostic scales | |||
| PSI (IV–V) | 6 (11.5) | 18 (42.9) | * 0.001 |
| CURB65 | 1 (0–1) | 2 (1–2) | * <0.001 |
| Analytical parameters on admission | |||
| C-reactive protein (mg/dL) | 15.07 (6.32–25.32) | 23.64 (9.65–33.44) | * 0.046 |
| Leukocytes (cell/mm3) | 12955 (8470–16800) | 15115 (10330–19710) | 0.090 |
| Neutrophils (%) | 81.3 (75.7–84.8) | 87 (81.6–90.3) | * 0.001 |
| Neutrophils (cell/mm3) | 10692 (6481–14203) | 13561 (7735–17597) | * 0.043 |
| Lymphocytes (%) | 8.8 (6.6–12.8) | 6.8 (4.2–8.9) | * 0.005 |
| Lymphocytes (cell/mm3) | 1061 (795–1518) | 854 (589–1292) | 0.057 |
| Outcomes | |||
| Length of stay (days) | 6 (4–8) | 7 (5–10) | 0.018 |
| Clinical stability achieved | 52 (100) | 38 (90.5) | * 0.023 |
| Time to clinical stability (days) | 2 (1–3) | 5 (3–7) | * <0.001 |
| Treatment failure | 2 (3.8) | 6 (14.3) | 0.071 |
| 30-days mortality | 0 (0) | 2 (4.8) | 0.112 |
Data presented as n (%) or median (interquartile range); COPD: chronic obstructive pulmonary disease; CURB65: confusion, urea, respiratory rate, blood pressure, 65 years; PSI: pneumonia severity index. * p < 0.05.