Table 3.
Univariate and multivariate proportional hazard model of PIWIL2 and other clinical variables for progression-free and overall survival of those patients with pancreatic tumor origin.
| Univariate PFS (95% CI) | Univariate OS (95% CI) | |||||||
|---|---|---|---|---|---|---|---|---|
| HR | Lower | Upper | p-Value | HR | Lower | Upper | p-Value | |
| Age (<65 years vs. >65 years) | 1.359 | 0.695 | 2.657 | 0.370 | 1.320 | 0.715 | 2.439 | 0.375 |
| Gender (Male vs. Female) | 1.420 | 0.814 | 2.478 | 0.217 | 1.083 | 0.657 | 1.785 | 0.756 |
| Adjuvant treatment (Yes vs. No) | 1.168 | 0.603 | 2.260 | 0.645 | 1.321 | 0.781 | 2.428 | 0.371 |
| Size (<2 cm vs. >2 cm) | 1.792 | 0.633 | 5.073 | 0.272 | 1.163 | 0.519 | 2.603 | 0.714 |
| Stage | 0.050 | 0.148 | ||||||
| IA | 1.000 | 1.000 | ||||||
| IB | 1.367 | 0.466 | 4.008 | 0.569 | 1.161 | 0.466 | 2.890 | 0.748 |
| IIA | 3.568 | 1.221 | 10.431 | 0.020 | 2.491 | 0.975 | 6.362 | 0.056 |
| IIB | 2.393 | 0.900 | 6.364 | 0.080 | 1.733 | 0.743 | 4.040 | 0.203 |
| Grade (low vs. high) | 1.156 | 0.492 | 2.716 | 0.740 | 1.138 | 0.540 | 2.395 | 0.734 |
| Lymph nodes involved (No vs. Yes) | 1.457 | 0.817 | 2.599 | 0.202 | 1.266 | 0.746 | 2.150 | 0.382 |
| Vascular invasion (No vs. Yes) | 1.466 | 0.809 | 2.658 | 0.208 | 1.427 | 0.827 | 2.464 | 0.202 |
| Neural invasion (No vs. Yes) | 1.815 | 0.936 | 3.521 | 0.078 | 1.819 | 1.000 | 3.310 | 0.050 |
| pT (I vs. II/III) | 1.690 | 0.841 | 3.396 | 0.141 | 1.505 | 0.797 | 2.841 | 0.207 |
| PIWIL2 (high vs. low) | 1.788 | 0.987 | 3.249 | 0.057 | 1.832 | 1.064 | 3.154 | 0.029 |
| Multivariate PFS (95% CI) | Multivariate OS (95% CI) | |||||||
|
Neural invasion (No vs. Yes) |
1.726 | 0.946 | 3.151 | 0.075 | ||||
| PIWIL2 (high vs. low) | 1.813 | 1.030 | 3.189 | 0.039 | ||||
PFS: progression-free survival; OS: Overall survival; HR: hazard ratio; CI: confidence interval; vs.: versus; cm: centimeters.