Obese monogenic models
|
Lepob/ob mice (mutated leptin gene) |
Obesity-induced hyperglycemia, with hyperphagic, obese, hyperinsulinaemic and hyperglycemic animals |
Treatments to improve insulin resistance |
|
|
[29] |
|
|
Leprdb/db mice (mutated leptin receptor gene) |
Treatments to improve β-cell function |
|
|
[30] |
Zucker Diabetic Fatty (ZDF) Rats (mutated leptin receptor gene) |
|
|
[31] |
|
Obese polygenic models
|
KK mice
|
Obesity-induced hyperglycemia |
Treatments to improve insulin resistance |
|
|
|
Otsuka Long-Evans Tokushima Fat (OLEFT) rat
|
Treatments to improve β-cell function |
|
|
[32,33] |
New Zealand Obese (NZO) mice
|
Some models show diabetic complications |
|
TallyHo/Jng mice
|
|
|
|
|
NoncNZO10/LtJ mice
|
|
|
Induced obesity models
|
High fat feeding (mice or rats)
|
Obesity-induced hyperglycemia |
Treatments to improve insulin resistance |
|
|
[31,33] |
Desert gerbil
|
Treatments to improve β-cell function |
|
|
Nile grass rat
|
Treatments to prevent diet-induced obesity |
|
Non-obese models
|
Goto-Kakizaki (GK) rat
|
Hyperglycemia induced by insufficient β-cell function or mass |
Treatments to improve β-cell function |
|
|
[31,33] |
Treatments to improve β-cell survival |
Genetically induced models of β-cell dysfunction
|
Human islet amyloid polypeptide-expressing (hIAPP) mice
|
Amyloid deposition in islets |
Treatments to prevent amyloid deposition |
|
|
[31,33] |
Treatments to improve β-cell function |
|
β-cell destruction due to ER stress |
Treatments to prevent ER stress |
|
|
Treatments to improve β-cell survival |
Non-rodent models
|
Cat models
|
Amyloid deposition in islets |
Treatments to improve β-cell function |
|
|
[31,33,34,35,36,37] |
β-cell destruction |
Treatments to prevent diet-induced obesity |
Old-world non-human primates
|
|
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