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72 amino-acid sequence of the MUC1-C cytoplasmic domain. Amino acids in large, red font have been reported as phosphorylation sites and kinases are indicated. The CQC motif is necessary for MUC1-C oligomerization and the RRK motif is necessary for MUC1-C binding to importin β and targeting to the nucleus. Also highlighted is the β-catenin, p53 and estrogen receptor (ER) α binding sites.
